反应详情

A solution of 4,7-difluoro-2-[3-methyl-2-(2-methyl-propenyl)-benzoylamino]-indan-2-carboxylic acid (392) (82 mg, 0.21 mmol) in MeOH (40 mL) is hydrogenated using 10% palladium/carbon catalyst at 40 bar and 30° C. using the Thales nanotechnology H-Cube for 5 h. The MeOH is concentrated to dryness in vacuo to give the product (393) as white solid powder.

1. customat 40 bar and 30° C.
2. customfor 5 h
3. concentrationThe MeOH is concentrated to dryness in vacuo