HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1048229Generated: November 1, 2026
Sodium hydride → (5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-(cyclopropylmethyl)piperidin-2-one
https://huagongshe.com/reaction/1048229
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | Bromomethylcyclopropane | HCID 81503 | — |
| Reactant | (5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)piperidin-2-one | HCID 58573791 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | (5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-(cyclopropylmethyl)piperidin-2-one | HCID 60154112 | — |
Reaction Steps
To a solution of 1.5 g (4.7 mmol) of (5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)piperidin-2-one (Example 1, Step E) in 9.4 mL of DMF was added sodium hydride (60% suspension in mineral oil, 244 mg, 6.1 mmol) at 0° C. The reaction was stirred at 0° C. for 20 min and then treated with cyclopropylmethyl bromide (759 μl, 5621 μmol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08569341B2 |
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| Source dataset | uspto-grants-2013_10 |
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| ORD ID | ord-400cfa05dbc34bbaa35a8292da2f28b5 |
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| Source note | uspto-grants-2013_10 |
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