反应详情

To a solution of 40 mg (90 μmol) of 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-(cyclopropylmethyl)-2-oxopiperidin-3-yl)acetohydrazide (Example 51) in 0.2 mL of toluene was added methyl acetimidate hydrochloride (13 mg, 116 μmol). The reaction mixture was heated to reflux for 14 h and then the reaction was concentrated under reduced pressure. Separation by reversed phase HPLC (10 to 90% AcCN/H2O in 45 min) provided the title compound as a colorless film.

1. temperatureThe reaction mixture was heated
2. temperatureto reflux for 14 h
3. concentrationthe reaction was concentrated under reduced pressure
4. customSeparation by reversed phase HPLC (10 to 90% AcCN/H2O in 45 min)