HCID 58573784, compound → HCID 178456033, compound

HRID 1048600Notes

Reaction equation

HRID 1048600 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C@@H:8]2[C@@H:13]([C:14]3[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][CH:15]=3)[N:12]([C@@H:21]([CH2:30][CH3:31])[CH2:22][N:23]3[CH2:27][CH2:26][CH2:25][S:24]3(=[O:29])=[O:28])[C:11](=[O:32])[C@@:10]([CH2:34][C:35]3[CH:40]=[CH:39][CH:38]=[C:37]([O:41]C)[N:36]=3)([CH3:33])[CH2:9]2)[CH:5]=[CH:6][CH:7]=1.OC1N=C(CC2(C)CCCNC2=O)C=CC=1>>[Cl:1][C:2]1[CH:3]=[C:4]([C@@H:8]2[C@@H:13]([C:14]3[CH:15]=[CH:16][C:17]([Cl:20])=[CH:18][CH:19]=3)[N:12]([C@@H:21]([CH2:30][CH3:31])[CH2:22][N:23]3[CH2:27][CH2:26][CH2:25][S:24]3(=[O:29])=[O:28])[C:11](=[O:32])[C@@:10]([CH2:34][C:35]3[CH:40]=[CH:39][CH:38]=[C:37]([OH:41])[N:36]=3)([CH3:33])[CH2:9]2)[CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 58573784HCID 58573784, compoundHCID 178421996HCID 178421996, compound

Product 1

HCID 178456033HCID 178456033, compound

Procedure

Following the procedure of Example 422 using the product of Example 424, (3S,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-4S)-1-(1,1-dioxidoisothiazolidin-2-yl)butan-2-yl)-3-((6-hydroxypyridin-2-yl)methyl)-3-methylpiperidin-2-one was obtained.

Workup

  1. customwas obtained

Sources & evidence

ORD record
ord-ec65e5da2870452ab485cb147586e0e2
Source dataset
uspto-grants-2013_10
Patent number
US08569341B2

Reaction notes

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