HCID 89875936, compound → HCID 89875665, compound

HRID 1048629Notes

Reaction equation

HRID 1048629 reaction equation
[CH3:1][O:2][CH2:3][C:4]1[C:9]([CH:10]=[CH2:11])=[CH:8][CH:7]=[CH:6][C:5]=1[N:12]1[C:16](=[O:17])[N:15]([CH3:18])[N:14]=[N:13]1>[Pd].CO>[CH3:1][O:2][CH2:3][C:4]1[C:9]([CH2:10][CH3:11])=[CH:8][CH:7]=[CH:6][C:5]=1[N:12]1[C:16](=[O:17])[N:15]([CH3:18])[N:14]=[N:13]1

Participants

4

Reactant 1

HCID 89875936HCID 89875936, compound

Product 1

HCID 89875665HCID 89875665, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A mixture of 1-(2-methoxymethyl-3-ethenylphenyl)-4-methyl-1,4-dihydrotetrazole-5-one described in Reference Preparation example 2219.7 g, palladium fibroin complex 3.02 g and methanol 1 L was stirred at room temperature under hydrogen atmosphere for eleven hours. The reaction mixtures were filtered and the filtrates were concentrated under reduced pressure. The resulting residues were subjected to a silica gel column chromatography to give 1-(2-methoxymethyl-3-ethylphenyl)-4-methyl-1,4-dihydrotetrazole-5-one 19.3 g.

Workup

  1. customThe reaction mixtures
  2. filtrationwere filtered
  3. concentrationthe filtrates were concentrated under reduced pressure

Sources & evidence

ORD record
ord-6b81f781846d48a0aeb34e4aeb6d5693
Source dataset
uspto-grants-2016_07
Patent number
US09380782B2

Reaction notes

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