HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1048635Generated: October 26, 2026
Dimethylformamide → 2-Methyl-3-(trifluoromethyl)benzoyl chloride
https://huagongshe.com/reaction/1048635
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 2-Methyl-3-(trifluoromethyl)benzoic acid | HCID 2775584 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-Methyl-3-(trifluoromethyl)benzoyl chloride | HCID 2775602 | — |
Reaction Steps
A mixture of 3-trifluoromethyl-2-methylbenzoic acid 5.00 g, oxalyl dichloride 3.42 g, N,N-dimethylformamide about 50 mg and tetrahydrofuran 200 mL was stirred at 25° C. for one hour. The reaction mixtures were concentrated under reduced pressure to give 3-trifluoromethyl-2-methylbenzoic acid chloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09380782B2 |
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| Source dataset | uspto-grants-2016_07 |
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| ORD ID | ord-76b70cdc255b4caba04d9fc9274317ae |
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| Source note | uspto-grants-2016_07 |
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