HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1048656Generated: October 30, 2026
Cyclopropylamine → N-cyclopropyl-2-nitroaniline
https://huagongshe.com/reaction/1048656
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Cyclopropylamine | HCID 69828 | — |
| Reactant | 1-Fluoro-2-nitrobenzene | HCID 73895 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | N-cyclopropyl-2-nitroaniline | HCID 10487549 | 96.2% |
Reaction Steps
To a solution of 1-fluoro-2-nitrobenzene (0.50 g, 3.5 mmol) in ethanol was added cyclopropyl amine (0.60 g, 10.5 mmol). The solution was heated to 80° C. overnight and concentrated. The residue was purified by biotage column chromatography to give N-cyclopropyl-2-nitroaniline (0.60 g)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09381196B2 |
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| Source dataset | uspto-grants-2016_07 |
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| ORD ID | ord-f55947f3bab349708f5c9b9c95740c9e |
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| Source note | uspto-grants-2016_07 |
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