Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | HCID 66778512 | HCID 66778512 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 66777345 | HCID 66777345 | 67.7% |
Reaction Steps
To a solution of methyl 8-(2-(cyclopropylamino)phenylamino)-8-oxooctanoate (390 mg) in toluene was added a drop of acetic acid. The reaction was heated to 110° C. overnight and concentrated. The residue was purified by biotage column chromatography to give methyl 7-(1-cyclopropyl-1H-benzo[d]imidazol-2-yl)heptanoate (249 mg)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09381196B2 |
|---|
| Source dataset | uspto-grants-2016_07 |
|---|
| ORD ID | ord-9418d7c4c00c4b24b753e5da58f9d89c |
|---|
| Source note | uspto-grants-2016_07 |
|---|
