HRID1048685

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID525

Malic acid

C4H6O5

HCID962

Water

H2O

结构：CN1CCc2cccc3c2[C@H]1Cc1ccc(O)c(O)c1-3

HCID6005

Apomorphine

C17H17NO2

PRODUCTS

生成物

HCID6005

Apomorphine

C17H17NO2

结构：CN1CCc2cccc3c2[C@H]1Cc1ccc(O)c(O)c1-3.O=C([O-])CC(O)C(=O)[O-]

HCID131735991

未命名化合物

PROCEDURE

实验过程

Apomorphine malate solution was prepared by dissolving apomorphine base in 0.1M Malic acid solution. Water was added to obtain solutions with a molar ratio of 1:1 apomorphine:malic acid, at a concentration of 2% apomorphine. The pH of each solution was 4.0. Table 5 shows the composition of each apomorphine organic salt solution.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-f504320fed6b4aacb8a6e71e66288196
来源数据集: uspto-grants-2016_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09381249B2
来源说明: uspto-grants-2016_07

反应 SMILES

[CH3:1][N:2]1[C@@H:11]2[CH2:12][C:13]3[CH:18]=[CH:17][C:16]([OH:19])=[C:15]([OH:20])[C:14]=3[C:9]3[C:10]2=[C:5]([CH:6]=[CH:7][CH:8]=3)[CH2:4][CH2:3]1.O.[C:22]([OH:30])(=[O:29])[CH:23]([CH2:25][C:26]([OH:28])=[O:27])[OH:24]>>[CH3:1][N:2]1[C@@H:11]2[CH2:12][C:13]3[CH:18]=[CH:17][C:16]([OH:19])=[C:15]([OH:20])[C:14]=3[C:9]3[C:10]2=[C:5]([CH:6]=[CH:7][CH:8]=3)[CH2:4][CH2:3]1.[C:22]([O-:30])(=[O:29])[CH:23]([CH2:25][C:26]([O-:28])=[O:27])[OH:24].[CH3:1][N:2]1[C@@H:11]2[CH2:12][C:13]3[CH:18]=[CH:17][C:16]([OH:19])=[C:15]([OH:20])[C:14]=3[C:9]3[C:10]2=[C:5]([CH:6]=[CH:7][CH:8]=3)[CH2:4][CH2:3]1