Hydrochloric Acid → HCID 178479508, compound

Participants

Reaction Conditions

Reaction Steps

190 mg (0.408 mmol) of N—(N-(tert-butoxycarbonyl)carbamimidoyl)-2-((3-((4-fluorophenyl)ethynyl)imidazo[1,2-a]pyridin-2-yl)methoxy)acetamide were dissolved in 2 ml of ethanol before adding 1.020 ml (4.08 mmol) of a 4N hydrochloric acid solution in dioxane. The solution was heated to 60° C. for 2 h. The solvent was evaporated in vacuo. By cooling, the crystallised solid was filtered and washed with ethanol. 85 mg (yield=52%) of N-carbamimidoyl-2-((3-((4-fluorophenyl)ethynyl)imidazo[1,2-a]pyridin-2-yl) methoxy)acetamide hydrochloride were obtained as a yellow solid. LC-MS: m/z=366 (MH+) UV purity at 254 nm=99%. 1H NMR (300 MHz, DMSO) δ 11.36 (s, 1H), 8.86 (d, J=6.7 Hz, 1H), 8.55 (d, J=28.4 Hz, 4H), 7.92-7.71 (m, 4H), 7.44-7.31 (m, 3H), 4.99 (s, 2H), 4.40 (s, 2H).

Provenance & Evidence