3,4-Dihydroxybenzaldehyde → HCID 11052728, compound

Participants

Reaction Steps

3,4-Dihydroxybenzaldehyde (2.3 g, 17 mmol) and 3-methylbut-2-enal (1 mL, 10 mmol) were dissolved in 3 mL of pyridine and refluxed overnight. Pyridine was evaporated under vacuum, and the crude reaction mixture was dissolved in methylene chloride. 9 (103 mg, 2.4%) was purified with silica gel chromatography with ethyl acetate/hexane (1/50). 1H NMR (CDCl3): δ 1.50 (s, 6H), 5.70 (d, J=10.1 Hz, 1H), 6.38 (d, J=10.1 Hz, 1H), 7.15 (d, J=2.14 Hz, 1H), 7.32 (d, J=1.83 Hz, 1H), 9.78 (s, 1H).

Provenance & Evidence