Hydrazine → HCID 178509232, compound

HRID 1048751Notes

Reaction equation

HRID 1048751 reaction equation
[NH2:1][NH2:2].Cl[C:4]1[C:5]([C:11]#[N:12])=[N:6][C:7]([I:10])=[CH:8][N:9]=1>C(O)CCC>[I:10][C:7]1[N:6]=[C:5]2[C:11]([NH2:12])=[N:2][NH:1][C:4]2=[N:9][CH:8]=1

Participants

4

Reactant 2

HCID 9321HydrazineHCID 866805553-Chloro-6-iodopyrazine-2-carbonitrile

Product 1

HCID 178509232HCID 178509232, compoundYield 86%

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Conditions

Temperature
110 °C

Procedure

0.74 ml (9.8 mmol) of hydrazine is added to 2.6 g (9.80 mmol) of a solution of 3-chloro-6-iodopyrazine-2-carbonitrile in 15 ml of butanol. The reaction mixture is heated at 110° C. for 5 hours and then left at room temperature overnight. The suspended solid is filtered, rinsed with butanol and then dried in an oven at 50° C. to yield 2.2 g (86%) of 5-iodo-1H-pyrazolo[3,4-b]pyrazine-3-amine in the form of a brown solid.

Workup

  1. filtrationThe suspended solid is filtered
  2. washrinsed with butanol
  3. customdried in an oven at 50° C.

Sources & evidence

ORD record
ord-7712cbfb3afa43b8b3beaaea7b2e23e0
Source dataset
uspto-grants-2016_07
Patent number
US09381195B2

Reaction notes

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