関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Serinol | HCID 68294 | — |
| 反応物 | Dimethyl 5-nitroisophthalate | HCID 83316 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | N1,N3-bis(1,3-dihydroxypropan-2-yl)-5-nitroisophthalamide | HCID 89544897 | 99.7% |
反応手順
Dimethyl 5-nitroisophthalate (120 g, 0.5 mol) and serinol (113.6 g, 1.25 mol) are dissolved in methanol (960 mL), and then heated to reflux for 48 h. Cooled to 20° C., the solid is collected filtration using vacuum and the filter cake washed with methanol (50 mL×3). The filter cake is then dried to constant weight to obtain 178.2 g product as a white powder in 99% yield.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US09382194B2 |
|---|
| 出典データセット | uspto-grants-2016_07 |
|---|
| ORD ID | ord-2b1457a970c64d9795b2a37ccee18817 |
|---|
| 出典メモ | uspto-grants-2016_07 |
|---|
