N1,N3-bis(1,3-dihydroxypropan-2-yl)-5-nitroisophthalamide → 5-amino-N,N'-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-1,3-benzenedicarboxamide

Participants

Reaction Conditions

Reaction Steps

N,N′-Bis-(2-hydroxy-1-hydroxymethyl-ethyl)-5-nitro-isophthalamide (40 g) is dissolved in water (600 mL), and then heated to 90° C. to dissolve. Raney Ni (5 g) is added, and allowed to react for 10 h under a H2 pressure of 1.5 MPa. Raney Ni is removed by filtration and the filter cake washed with 20-30 mL of water. The filtrate and washings are combined to obtain the aqueous solution of 5-Amino-N,N′-bis-(2-hydroxy-1-hydroxymethyl-ethyl)-isophthalamide, which can be utilized directly in the iodination reaction or concentrated and then re-crystallized using methanol to obtain solid product.

Provenance & Evidence