Hydrochloric Acid → HCID 118160628, compound

Participants

Reaction Steps

To a mechanically stirring solution at room temperature under N2 of tert-butyl 5-((S)-3-((R)-2-acetamido-3-amino-3-oxopropylthio)-2-(3-(tert-butoxycarbonylamino)propanamido)-3-oxopropyl)-1H-imidazole-1-carboxylate (45d, 104.1 g, 182.4 mmol) in 1200 mL of dioxane was added dropwise hydrogen chloride, 4 N solution in dioxane (106 mL, 640 mmol). After addition of ˜50 mL of the HCl solution, solid formed. After complete addition, the sample was stirred at room temperature under N2 for 3 h, filtered and vacuum dried to give 97.9 g (>100%) of titled compound as white solid. MS (APCI) m/z 371 [parent+H]+.

Provenance & Evidence