Triethylamine → 1-(4-Fluorophenyl)-4-oxo-6-vinyl-1,4-dihydroquinoline-3-carboxamide

Participants

Reaction Conditions

Reaction Steps

To a solution of compound E (450 mg, 1.25 mmol), triethylamine (174 μL, 1.25 mmol), and Pd(dppf)Cl2 CH2Cl2 (18.2 mg, 0.025 mmol) in 1-propanol (8.3 mL) was added potassium vinyltrifluoroborate (200 mg, 1.50 mmol). The reaction was purged with argon and stirred at 100° C. for 16 hours. The reaction was filtered over Celite® and washed very well with a 5% MeOH in DCM solution and concentrated in vacuo to give 385 mg (100%) of the title compound that was used without further purification. ES-MS [M+1]+: 309.2.

Provenance & Evidence