反应详情

温度

150 °C

Compound T (11 mg, 0.026 mmol, 1.0 eq) was dissolved in 7N ammonia in methanol (1 mL) in a microwave vial and heated in a microwave reactor at 150° C. for 60 minutes. The reaction was concentrated and purified by reverse phase chromatography to afford 6.7 mg (65%) of the title compound as a white solid. 1H NMR (400 MHz, DMSO-d6) δ 9.24 (d, J=4.4 Hz, 1H), 8.55 (s, 2H), 8.53 (s, 1H), 8.20 (d, J=2.0 Hz, 1H), 7.76-7.71 (m, 2H), 7.62-7.58 (m, 2H), 7.51 (t, J=8.7 Hz, 2H), 6.99 (d, J=8.7 Hz, 1H), 3.06 (t, J=8.3 Hz, 2H), 2.90 (t, J=8.3 Hz, 2H), 2.53 (s, 3H); ES-MS [M+1]+: 403.2.

1. concentrationThe reaction was concentrated
2. custompurified by reverse phase chromatography