反应详情

A stirred solution of 2-bromo-5-(methylamino)-4-nitrobenzonitrile (0.3 g, 0.001 mol) in EtOH (10 ml) was hydrogenated using Pd/C for 2 h at room temperature. The reaction was filtered through CELITE® and the filter bed was thoroughly washed with EtOH. The resulting solution was concentrated to provide 4-amino-2-bromo-5-(methylamino)benzonitrile, as a brownish a solid. Crude LCMS (M+1): 226.12. Purity: 63%.

1. customfor 2 h
2. customat room temperature
3. filtrationThe reaction was filtered through CELITE®
4. washthe filter bed was thoroughly washed with EtOH
5. concentrationThe resulting solution was concentrated