Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Isopropanol | HCID 3776 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Vilazodone | HCID 6918314 | — |
| Solvent | Benzyl Alcohol | HCID 244 | — |
| Product | Benzyl Alcohol | HCID 244 | — |
| Product | 2-benzofurancarboxamide, 5-(4-(4-(5-cyano-1H-indol-3-yl)butyl)-1-piperazinyl)-, hydrochloride (1:1) | HCID 6918313 | — |
Reaction Steps
1-[4-(5-Cyanoindol-3-yl)butyl]-4-(2-carbamoyl-benzofuran-5-yl)-piperazine (1 g) was dissolved in benzyl alcohol (10 ml) under inert gas atmosphere at 20-25° C. To the clear solution was added HCl in isopropanol (0.55 g, 1.2 eq). The resulting suspension was stirred for 20 h at 20-25° C. Ethyl acetate (5 ml) was added to the suspension followed by stirring for 3 h at 35° C. The solid was filtered, washed with ethyl acetate (2×5 ml) and dried at 65° C. to afford 0.9 g hemi solvate of 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoyl-benzofuran-5-yl)-piperazine hydrochloride with benzyl alcohol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09382233B2 |
|---|
| Source dataset | uspto-grants-2016_07 |
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| ORD ID | ord-0c477d24667e4fd4b68f181f21da4d0f |
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| Source note | uspto-grants-2016_07 |
|---|
