Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Isopropanol | HCID 3776 | — |
| Reactant | Vilazodone | HCID 6918314 | — |
| Solvent | Benzyl Alcohol | HCID 244 | — |
| Product | Benzyl Alcohol | HCID 244 | — |
| Product | 2-benzofurancarboxamide, 5-(4-(4-(5-cyano-1H-indol-3-yl)butyl)-1-piperazinyl)-, hydrochloride (1:1) | HCID 6918313 | — |
Reaction Steps
1-[4-(5-Cyanoindol-3-yl)butyl]-4-(2-carbamoyl-benzofuran-5-yl)-piperazine (1 g) in benzyl alcohol (5 ml) was heated under inert gas atmosphere to 45° C. To the suspension was added HCl in isopropanol (0.55 g, 1.2 eq) followed by cooling to 20-25° C. and stirring for about 20 h. The suspension was heated to 35° C. and maintained for 3 h. The solid was filtered, washed with MTBE (2×5 ml) and dried at 65° C. to afford 0.94 g hemi solvate of 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoyl-benzofuran-5-yl)-piperazine hydrochloride with benzyl alcohol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09382233B2 |
|---|
| Source dataset | uspto-grants-2016_07 |
|---|
| ORD ID | ord-5bdadfdaa0624b57b1307f13071382a3 |
|---|
| Source note | uspto-grants-2016_07 |
|---|
