Hydrochloric Acid → tert-butyl-4-[(1R)-1-aminoethyl]benzoate hydrochloride

Participants

Reaction Steps

To a 2-dram vial was added tert-butyl 4-[(1R)-1-{[(S)-tert-butylsulfinyl]amino}ethyl]benzoate (0.0586 g, 0.180 mmol), hydrochloric acid (0.14 mL, 0.54 mmol, 4.0 M in 1,4-dioxane), and methanol (2 mL). The mixture was stirred at rt for 2 h. The solvent was then completely removed to give tert-butyl-4-[(1R)-1-aminoethyl]benzoate hydrochloride as a white solid. LC-MS: (FA) ES+ 222.

Provenance & Evidence