Hydrochloric Acid → tert-butyl-4-[(1R)-1-aminoethyl]benzoate hydrochloride

Participants

Reaction Steps

To a microwave vial containing tert-butyl 4-[(1R)-1-{[(S)-tert-butylsulfinyl]amino}ethyl]benzoate (0.052 g, 0.16 mmol) was added hydrochloric acid (0.08 mL, 0.32 mmol, 4.0 M of in 1,4-dioxane), and methanol (2 mL). This mixture was stirred at rt for 2 h, and then evaporated to dryness to afford tert-butyl-4-[(1R)-1-aminoethyl]benzoate hydrochloride as a white solid. LC-MS: (FA) ES+ 222.

Provenance & Evidence