Chloroform → HCID 67468253, compound

HRID 1049120Notes

Reaction equation

HRID 1049120 reaction equation
[Br:1][C:2]1[CH:3]=C[C:5]2[NH:6][C:7]3[C:12]([S:13][C:14]=2[CH:15]=1)=[CH:11][C:10]([Br:16])=[CH:9][CH:8]=3.S(Cl)([Cl:20])(=O)=O.[CH:22]([Cl:25])(Cl)Cl>>[Br:1][C:2]1[CH:3]=[C:22]([Cl:25])[C:5]2[NH:6][C:7]3[C:12]([S:13][C:14]=2[CH:15]=1)=[CH:11][C:10]([Br:16])=[CH:9][C:8]=3[Cl:20]

Participants

4

Reactant 3

HCID 6212ChloroformHCID 24648Sulfuryl chlorideHCID 35471153,7-dibromo-10H-phenothiazine

Product 1

HCID 67468253HCID 67468253, compound

Procedure

The 3,7-dibromophenothiazine (6.25 g, 17.5 mmol) was dissolved in 200 mL of chloroform (CHCl3). Sulfuryl chloride (SO2Cl2, 3.13 mL, 38.5 mmol) was added dropwise over 15 min. The dark mixture was stirred at RT for 36 h. The mixture was then filtered and the solid washed with CHCl3. The solid was collected and stirred in Et2O and the resulting green solid was filtered off and dried under vacuum to give a quantitative yield of the desired product.

Workup

  1. filtrationThe mixture was then filtered
  2. washthe solid washed with CHCl3
  3. customThe solid was collected
  4. stirringstirred in Et2O
  5. filtrationthe resulting green solid was filtered off
  6. customdried under vacuum

Sources & evidence

ORD record
ord-a456c3eb5e5e4abb8eade8b8fe51ef06
Source dataset
uspto-grants-2016_07
Patent number
US09382221B2

Reaction notes

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