HCID 90403112, compound → HCID 90403028, compound

Participants

Reaction Steps

A solution of 2-methyl-5-(4-((2-methyl-6-nitropyridin-3-yl)oxy)pyridin-2-yl)thiazole (0.094 g, 0.286 mmol) in MeOH (30 mL) was flushed with Ar, treated with 10% Pd/C (50% wet, 0.305 g, 0.286 mmol) and hydrogenated (1 atm) overnight. The solids were removed via filtration through diatomaceous earth, washed well with MeOH and the filtrate was concentrated to dryness to afford 6-methyl-5-((2-(2-methylthiazol-5-yl)pyridin-4-yl)oxy)pyridin-2-amine (60 mg, 70%). 1H NMR (400 MHz, DMSO-d6): δ 8.34 (d, J=5.8 Hz, 1H), 8.28 (s, 1H), 7.49 (d, J=2.4 Hz, 1H), 7.19 (d, J=8.7 Hz, 1H), 6.58 (dd, J=5.8, 2.4 Hz, 1H), 6.34 (d, J=8.7 Hz, 1H), 5.96 (s, 2H), 2.65 (s, 3H), 2.07 (s, 3H); MS (ESI) m/z: 299.1 (M+H+).

Provenance & Evidence