HCID 90403425, compound → HCID 90403203, compound

Participants

Reaction Steps

A solution of 5-(4-((6-nitropyridin-3-yl)oxy)pyridin-2-yl)oxazole (0.092 g, 0.324 mmol) in MeOH (10 mL) was treated with 10% Pd/C (50% wet, 0.034 g, 0.032 mmol) and hydrogenated (1 atm) for 5 h. The solid was removed via filtration through diatomaceous earth and the filtrate concentrated to dryness to afford 5-((2-(oxazol-5-yl)pyridin-4-yl)oxy)pyridin-2-amine (73 mg, 89%). 1H NMR (400 MHz, DMSO-d6): δ 8.47 (s, 1H), 8.46 (d, J=5.7 Hz, 1H), 7.84 (d, J=2.9 Hz, 1H), 7.76 (s, 1H), 7.32 (dd, J=8.9, 3.0 Hz, 1H), 7.15 (d, J=2.5 Hz, 1H), 6.86 (dd, J=5.7, 2.5 Hz, 1H), 6.53 (d, J=8.9 Hz, 1H), 6.06 (s, 2H); MS (ESI) m/z: 255.1 (M+H+).

Provenance & Evidence