HCID 90425395, compound → HCID 90426427, compound

Participants

Reaction Steps

A solution of 6′-(bis(tert-butoxycarbonyl)amino)-4-((6-nitropyridin-3-yl)oxy)-[2,3′-bipyridine](0.600 g, 1.178 mmol) in EtOAc (15 mL) and MeOH (5 mL) was treated with 10% Pd/C (50% wet, 0.125 g, 1.178 mmol) and hydrogenated (1 atm) for 16 h. The solids were removed via filtration through diatomaceous earth, washed with EtOAc and the filtrate concentrated to dryness to afford 6′-(bis(tert-butoxycarbonyl)amino)-4-((6-aminopyridin-3-yl)oxy)-[2,3′-bipyridine](0.55 g, 97%) as a white amorphous solid. 1H NMR (400 MHz, DMSO-d6): δ 9.06 (d, J=2.5 Hz, 1H), 8.53 (d, J=5.7 Hz, 1H), 8.46 (dd, J=8.5, 2.5 Hz, 1H), 7.84 (d, J=3.0 Hz, 1H), 7.63 (d, J=2.4 Hz, 1H), 7.48 (d, J=8.0 Hz, 1H), 7.32 (dd, J=8.9, 3.0 Hz, 1H), 6.79 (dd, J=5.7, 2.4 Hz, 1H), 6.53 (d, J=8.9 Hz, 1H), 6.03 (s, 2H), 1.40 (s, 18H); MS (ESI) m/z: 480.2 (M+H+).

Provenance & Evidence