HCID 90403164, compound → HCID 90403026, compound

Participants

Reaction Steps

A solution of 5-(4-((6-nitropyridin-3-yl)oxy)pyridin-2-yl)thiazole (0.18 g, 0.599 mmol) in EtOAc (10 mL) and MeOH (3 mL) was treated with 10% Pd/C (50% wet, 0.064 g, 0.060 mmol) and hydrogenated (1 atm) for 16 h. The solids were removed via filtration through diatomaceous earth, washed with EtOAc and the filtrate was concentrated to dryness to afford 5-((2-(thiazol-5-yl)pyridin-4-yl)oxy)pyridin-2-amine (150 mg, 74%). MS (ESI) m/z: 271.1 (M+H+).

Provenance & Evidence