HCID 90403394, compound → HCID 178433219, compound

Participants

Reaction Steps

A solution of (4-(4-((2-Methyl-6-(3-pivaloylureido)pyridin-3-yl)oxy)pyridin-2-yl)-1H-1,2,3-triazol-1-yl)methyl pivalate (0.16 g, 0.314 mmol) and TEA (0.175 mL, 1.256 mmol) in MeOH (5 mL) was stirred at 40° C. for ˜40 h. The solvent was evaporated to dryness and the residue was purified by silica gel chromatography (MeOH/DCM), and lyophilized from MeCN/H2O to afford N-((5-((2-(1H-1,2,3-triazol-4-yl)pyridin-4-yl)oxy)-6-methylpyridin-2-yl)carbamoyl)pivalamide (62 mg, 50%) as a white solid. 1H NMR (400 MHz, DMSO-d6): δ 11.18 (s, 1H), 10.40 (br s, 1H), 8.49 (d, J=5.9 Hz, 1H), 8.23 (br s, 1H), 7.93 (br s, 1H), 7.70 (d, J=8.8 Hz, 1H), 7.35 (br s, 1H), 6.90 (d, J=5.5 Hz, 1H), 2.26 (s, 3H), 1.21 (s, 9H); MS (ESI) m/z: 396.2 (M+H+).

Provenance & Evidence