HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 2,7-Naphthyridin-1-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | Phosphorus pentachloride | HCID 24819 | — |
| Reactant | 4-Bromo-1-chloro-2,7-naphthyridine | HCID 90092718 | — |
| Product | 2,7-Naphthyridin-1-amine | HCID 12884786 | — |
Reaction Steps
Bromination gives 4-bromo-2,7-naphthyridin-1(2H)-one CAS 959558-27-1, which is converted into 4-bromo-1-chloro-2,7-naphthyridine by chlorinating compounds, such as POCl3 and/or PCl5. Reaction with ammonia or ammonia equivalents gives 2,7-naphthyridin-1-ylamine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09382244B2 |
| Source dataset | uspto-grants-2016_07 |
| ORD ID | ord-972a79fc549d4e0ab3a08e01423b1b67 |
| Source note | uspto-grants-2016_07 |