HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 1-(Benzenesulfonyl)-3-bromo-2-methyl-1H-pyrrolo[2,3-b]pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | 2-methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine | HCID 1236372 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-(Benzenesulfonyl)-3-bromo-2-methyl-1H-pyrrolo[2,3-b]pyridine | HCID 11152320 | 93.6% |
Reaction Steps
25 g of NBS in 75 ml of DMF are added to a solution of 34.8 g of 2-methyl-1-(benzenesulfonyl)-7-azaindole in 75 ml of DMF. The mixture is stirred at room temperature for 1 h, poured into water, the precipitate which has precipitated out is separated off, washed with water and dried, giving 42 g of 3-bromo-2-methyl-1-(benzenesulfonyl)-7-azaindole, M˜351.22 g/mol, M+H found 351.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09382244B2 |
| Source dataset | uspto-grants-2016_07 |
| ORD ID | ord-651a014dff0845afa325c3b643a2d9c9 |
| Source note | uspto-grants-2016_07 |