Cesium carbonate → HCID 73438552, compound

Participants

Reaction Steps

A mixture of 23 g of 4-(1-benzenesulfonyl-2-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-2,7-naphthyridin-1-ylamine and 26 g of caesium carbonate in 400 ml of THF/trifluoroethanol (1:1 vol) is heated under reflux for 20 h. The mixture is cooled, the solvent is removed, and the product is purified by means of flash chromatography over 220 g of silica with a methanol gradient in ethyl acetate with 150 ml/min with UV detection at 254 nm, giving 12.2 g of 4-(2-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-2,7-naphthyridin-1-ylamine, M˜275.31, M+H found 276.2;

Provenance & Evidence