反应详情

To a solution of 2′-fluoro-5′-methoxy-2-neopentyl-[1,1′-biphenyl]-4-ol (388 mg), ethyl 3-cyclopropyl-3-(3-(hydroxymethyl)phenyl)propanoate (261 mg) and triphenylphosphine (413 mg) in THF (10 mL) was added a 40% solution of diethyl azodicarboxylate in toluene (620 μL) at 0° C., and the mixture was stirred at room temperature for 70 min. The reaction mixture was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (310 mg) as a pale-yellow oil.

1. concentrationThe reaction mixture was concentrated under reduced pressure
2. customthe residue was purified by silica gel column chromatography (ethyl acetate/hexane)