Sodium Methoxide → Sodium 3-cyclopropyl-3-(3-(((2-(2,2-dimethylpropyl)-2'-fluoro-5'-methoxybiphenyl-4-yl)oxy)methyl)phenyl)propanoate

Participants

Reaction Steps

A 28% solution of sodium methoxide (100 mg) in methanol was added to a solution of 3-cyclopropyl-3-(3-(((2-(2,2-dimethylpropyl)-2′-fluoro-5′-methoxybiphenyl-4-yl)oxy)methyl)phenyl)propanoic acid (255 mg) in methanol (2.5 mL), and the mixture was stirred at room temperature for 5 min. The reaction mixture was concentrated under reduced pressure to give the title compound (252 mg) as a white amorphous solid.

Provenance & Evidence