Hydrochloric Acid → HCID 117759805, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of ethyl 3-cyclopropyl-3-(3-(((2′-fluoro-5′-methoxy-2-neopentyl-[1,1′-biphenyl]-4-yl)sulfonyl)methyl)phenyl)propanoate (204 mg) in ethanol (3.6 mL) was added 2N aqueous sodium hydroxide solution (898 μl) at room temperature, and the mixture was stirred at 50° C. for 2 hr. The reaction mixture was cooled to 0° C., neutralized with 1N hydrochloric acid, and extracted with ethyl acetate. The extract was washed with saturated brine and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure to give the title compound (133 mg) as a white amorphous solid.

Provenance & Evidence