Dimethylformamide → 5-(Benzyloxy)-2-methoxy-3-neopentylpyridine

Participants

Reaction Conditions

Reaction Steps

To a mixture of 6-methoxy-5-neopentylpyridin-3-ol (2.00 g), potassium carbonate (4.25 g) and DMF (20 mL) was added benzyl bromide (2.40 mL) at room temperature, and the mixture was stirred at 50° C. for 30 min. Water was added to the reaction mixture at room temperature, and the mixture was extracted with ethyl acetate. The extract was washed with water and saturated brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to give a crude product of the title compound as a colorless oil. This compound was used for the next step without further purification.

Provenance & Evidence