Hydrochloric Acid → HCID 117760154, compound

Participants

Reaction Steps

To a solution of ethyl 3-(3-(((2-(5-(tert-butyl)-1,3,4-oxadiazol-2-yl)-2′-fluoro-5′-methoxy-[1,1′-biphenyl]-4-yl)oxy)methyl)phenyl)-3-cyclopropylpropanoate (115 mg) in methanol (1.0 mL) and THF (1.0 mL) was added 1N aqueous sodium hydroxide solution (0.60 mL), and the mixture was stirred at room temperature for 2 hr. Water and 1N hydrochloric acid were added, and the mixture was extracted with ethyl acetate. The extract was washed with saturated brine and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure and the residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (62 mg) as a colorless oil.

Provenance & Evidence