Hydrochloric Acid → HCID 117760052, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of ethyl 3-cyclopropyl-3-(3-(((2′-fluoro-5′-methoxy-2-(methoxymethoxy)biphenyl-4-yl)oxy)methyl)phenyl)propanoate (1.84 g) in THF (30 mL) was added 6N hydrochloric acid (3.0 mL), and the mixture was stirred at 50° C. for 4 hr. To the reaction mixture was added saturated aqueous sodium hydrogen carbonate solution, and the mixture was extracted with ethyl acetate. The extract was washed with saturated brine and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure and the residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (788 mg) as a colorless oil.

Provenance & Evidence