Water → HCID 117760118, compound

Participants

Reaction Conditions

Reaction Steps

Under an argon atmosphere, to a solution of ethyl 3-cyclopropyl-3-(3-(((5-neopentyl-6-(((trifluoromethyl)sulfonyl)oxy)pyridin-3-yl)oxy)methyl)phenyl)propanoate (200 mg) in DMF (5.0 mL) were added 2-fluoro-5-methoxyphenylboronic acid (80 mg), 2.0M aqueous sodium carbonate solution (0.52 mL) and tetrakistriphenylphosphinepalladium (40 mg), and the mixture was stirred at 90° C. for 1 hr. Water was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The extract was washed with saturated brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure, and the residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (27 mg) as a colorless oil.

Provenance & Evidence