Methanol → 5-Bromo-2-(methoxycarbonyl)pyridine 1-oxide

Participants

Reaction Steps

To a solution of 5-bromo-2-carboxypyridine 1-oxide (19.6 g) in methanol (300 mL) was added dropwise thionyl chloride (37.1 g) at 0° C., and the mixture was heated under reflux for 1 hr. The reaction mixture was concentrated under reduced pressure, and the residue was washed with ethyl acetate to give the title compound (22.0 g) as a crude amorphous solid. This compound was used for the next step without further purification.

Provenance & Evidence