Hydrochloric Acid → HCID 117759672, compound

Participants

Reaction Steps

To a solution of ethyl 3-(3-(((2-(5-(tert-butyl)-1,3,4-thiadiazol-2-yl)-2′-fluoro-5′-methoxy-[1,1′-biphenyl]-4-yl)oxy)methyl)phenyl)-3-cyclopropylpropanoate (129 mg) in methanol (1.5 mL) and THF (1.5 mL) was added 1N aqueous sodium hydroxide solution (0.66 mL), and the mixture was stirred at room temperature for 9 hr. Water and hydrochloric acid were added, and the reaction mixture was extracted with ethyl acetate. The extract was washed with saturated brine, and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure, and the residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (122 mg) as a colorless oil.

Provenance & Evidence