Trifluoroacetic acid → HCID 117759849, compound

Participants

Reaction Steps

Trifluoroacetic acid (5.0 mL) was added to 2-(2′-fluoro-5′-methoxy-4-((4-methoxybenzyl)oxy)-[1,1′-biphenyl]-2-yl)-5-(trifluoromethyl)-1,3,4-thiadiazole (299 mg) and anisole (0.66 mL) at room temperature, and the mixture was stirred at room temperature for 1.5 hr. The reaction mixture was concentrated under reduced pressure, aqueous sodium hydrogen carbonate solution was added, and the mixture was extracted with ethyl acetate. The extract was washed with saturated brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure, and the residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (200 mg) as a white solid.

Provenance & Evidence