HCID 131736031, compound → HCID 117759933, compound

Participants

Reaction Steps

To a solution of ethyl 3-(2-cyanocyclopropyl)-3-(3-((methoxymethoxy)methyl)phenyl)acrylate (490 mg) obtained in Example 86, step 4, in ethyl acetate (8 mL) was added 10% palladium-activated carbon (100 mg) and, under a hydrogen atmosphere, the mixture was stirred at room temperature for 1 hr. The reaction mixture was filtered, and the filtrate was concentrated under reduced pressure to give a crude product (459 mg) of the title compound as a colorless oil. This compound was used for the next step without further purification.

Provenance & Evidence