Thionyl Chloride → HCID 117759605, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of ethyl 3-cyclopropyl-3-(3-(((2′-fluoro-2-(hydroxy(1-methylcyclopentyl)methyl)-5′-methoxybiphenyl-4-yl)oxy)methyl)phenyl)propanoate (99 mg) in THF (3 mL) was added thionyl chloride (64 μL) and the mixture was stirred at 50° C. for 15 hr. The solvent was evaporated under reduced pressure, and the residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (95 mg) as a colorless oil.

Provenance & Evidence