Water → 2-(Bromomethyl)-2'-fluoro-5'-methoxy-4-((4-methoxybenzyl)oxy)biphenyl

Participants

Reaction Steps

To a solution of (2′-fluoro-5′-methoxy-4-((4-methoxybenzyl)oxy)biphenyl-2-yl)methanol (472 mg) and triphenylphosphine (675 mg) in toluene (10 mL) was added carbon tetrabromide (635 mg), and the mixture was stirred at room temperature for 1 hr. Water was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The extract was washed with saturated brine, and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure, and the residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (434 mg) as a colorless oil.

Provenance & Evidence