1,3-Dibromopropane → HCID 131736035, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 3-(4-((tert-butyl(dimethyl)silyl)oxy)-2′-fluoro-5′-methoxybiphenyl-2-yl)propanenitrile (165 mg) and 1,3-dibromopropane (67 μL) in THF (4 mL) was added a solution (1 M, 1.1 mL) of lithium bis(trimethylsilyl)amide in THF at 0° C., and the mixture was stirred at 0° C. for 1 hr. To the reaction mixture was added saturated aqueous ammonium chloride solution, and the mixture was extracted with ethyl acetate. The extract was washed with saturated brine, and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure, and the residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (116 mg) as a colorless oil.

Provenance & Evidence