Sodium sulfate decahydrate → HCID 117759702, compound

Participants

Reaction Steps

Under a nitrogen atmosphere, to a suspension of lithium aluminum hydride (28.2 mg) in THF (5.7 mL) was added dropwise a solution of 1-(2′-fluoro-5′-methoxy-4-((4-methoxybenzyl)oxy)-[1,1′-biphenyl]-2-yl)-2,2-dimethylbutan-1-one (162.2 mg) in THF (1.9 mL) at 0° C., and the mixture was stirred for 10 min. To the reaction mixture was added a small portion of sodium sulfate decahydrate at 0° C., and the mixture was filtered. The solvent was evaporated under reduced pressure, and the residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (155 mg) as a colorless oil.

Provenance & Evidence