1-(2'-Fluoro-5'-methoxy-4-((4-methoxybenzyl)oxy)-[1,1'-biphenyl]-2-yl)-4,4-dimethylpentan-1-ol → 2-(4,4-Dimethylpentyl)-2'-fluoro-5'-methoxy-[1,1'-biphenyl]-4-ol

Participants

Reaction Steps

A solution (8.7 mL) of 1-(2′-fluoro-5′-methoxy-4-((4-methoxybenzyl)oxy)-[1,1′-biphenyl]-2-yl)-4,4-dimethylpentan-1-ol (394 mg) and 10% palladium-carbon (168 mg) in methanol was stirred under a hydrogen balloon atmosphere at room temperature for 9 hr. The reaction mixture was filtered, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (256 mg) as a colorless oil.

Provenance & Evidence