HCID 118006008, compound → HCID 118005892, compound

Participants

Reaction Steps

Pyridinium chlorochromate (PCC, 1.9 g, 9.0 mmol) was added to a solution of 31 (1.1 g, 4.5 mmol) in DCM (15 mL), and the mixture was stirred for 2 h prior to filtration through a short pad of silica gel. The filtrate was then concentrated rotary evaporation, and purified by column chromatography to give 5-bromo-7-fluoro-2-naphthaldehyde (32) (88%). 1H NMR (400 MHz, CDCl3) δ 10.20 (s, 1H), 8.34 (d, J=8.8 Hz, 1H), 8.29 (s, 1H), 8.01 (d, J=8.8 Hz, 1H), 7.77 (dd, J=8.0, 2.3 Hz, 1H), 7.64 (d, J=8.6 Hz, 1H). GC-MS (ES) for C11H6BrFO [M+1]+253.

Provenance & Evidence