HRID1049677

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID67607

Benzoyl chloride, 4-(trifluoromethyl)-

C8H4ClF3O

结构：O=C1CC(=O)N(c2ccc(NC(=O)c3ccccc3)cc2)c2ccc3ccccc3c2N1

HCID71656971

未命名化合物

结构：Nc1ccc(N2C(=O)CC(=O)Nc3c2ccc2ccccc32)cc1

HCID117699167

未命名化合物

PRODUCTS

生成物

结构：O=C1CC(=O)N(c2ccc(NC(=O)c3ccc(C(F)(F)F)cc3)cc2)c2ccc3ccccc3c2N1

HCID71657063

未命名化合物

收率 41%

PROCEDURE

实验过程

By using 5-(4-aminophenyl)-1H-naphtho[1,2-b][1,4]diazepine-2,4(3H,5H)-dione (16 mg, 0.050 mmol) obtained in Example 1, (3), and 4-(trifluoromethyl)benzoyl chloride (16 mg, 0.077 mmol), the title compound (10 mg, yield 41%) was obtained as white crystals in the same manner as that of Example 1, (4).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-ac31a6fc79cb406e86dd09331b77ba82
来源数据集: uspto-grants-2016_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09382236B2
来源说明: uspto-grants-2016_07

反应 SMILES

[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:14](=[O:15])[CH2:13][C:12](=[O:16])[NH:11][C:10]3[C:17]4[C:22]([CH:23]=[CH:24][C:9]2=3)=[CH:21][CH:20]=[CH:19][CH:18]=4)=[CH:4][CH:3]=1.[F:25][C:26]([F:37])([F:36])[C:27]1[CH:35]=[CH:34][C:30]([C:31](Cl)=[O:32])=[CH:29][CH:28]=1.C(NC1C=CC(N2C(=O)CC(=O)NC3C4C(C=CC2=3)=CC=CC=4)=CC=1)(=O)C1C=CC=CC=1>>[F:25][C:26]([F:36])([F:37])[C:27]1[CH:35]=[CH:34][C:30]([C:31]([NH:1][C:2]2[CH:7]=[CH:6][C:5]([N:8]3[C:14](=[O:15])[CH2:13][C:12](=[O:16])[NH:11][C:10]4[C:17]5[C:22]([CH:23]=[CH:24][C:9]3=4)=[CH:21][CH:20]=[CH:19][CH:18]=5)=[CH:4][CH:3]=2)=[O:32])=[CH:29][CH:28]=1