HRID1049744

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID24386

Thionyl chloride

Cl2OS

HCID12357674

2-[(Propan-2-yl)oxy]benzoic acid

C10H12O3

结构：O=C1CC(=O)N(CCNC(=O)c2ccccc2I)c2ccc3ccccc3c2N1

HCID117699125

未命名化合物

结构：Nc1ccc(N2C(=O)CC(=O)Nc3c2ccc2ccccc32)cc1

HCID117699167

未命名化合物

PRODUCTS

生成物

结构：CC(C)Oc1ccccc1C(=O)Nc1ccc(N2C(=O)CC(=O)Nc3c2ccc2ccccc32)cc1

HCID117699454

未命名化合物

收率 75.1%

PROCEDURE

实验过程

2-Isopropoxybenzoic acid (36 mg, 0.2 mmol) was treated with thionyl chloride in the same manner as that of Example 13, and then by using the resultant together with 5-(4-aminophenyl)-1H-naphtho[1,2-b][1,4]diazepine-2,4(3H,5H)-dione (32 mg, 0.1 mmol), the title compound (36 mg, yield 75%) was obtained as white crystals in the same manner as that of Example 1, (4).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-196d5052375f4846a75b0c2ae975e80d
来源数据集: uspto-grants-2016_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09382236B2
来源说明: uspto-grants-2016_07

反应 SMILES

[CH:1]([O:4][C:5]1[CH:13]=[CH:12][CH:11]=[CH:10][C:6]=1[C:7]([OH:9])=O)([CH3:3])[CH3:2].S(Cl)(Cl)=O.[NH2:18][C:19]1[CH:24]=[CH:23][C:22]([N:25]2[C:31](=[O:32])[CH2:30][C:29](=[O:33])[NH:28][C:27]3[C:34]4[C:39]([CH:40]=[CH:41][C:26]2=3)=[CH:38][CH:37]=[CH:36][CH:35]=4)=[CH:21][CH:20]=1.IC1C=CC=CC=1C(NCCN1C(=O)CC(=O)NC2C3C(C=CC1=2)=CC=CC=3)=O>>[CH:1]([O:4][C:5]1[CH:13]=[CH:12][CH:11]=[CH:10][C:6]=1[C:7]([NH:18][C:19]1[CH:24]=[CH:23][C:22]([N:25]2[C:31](=[O:32])[CH2:30][C:29](=[O:33])[NH:28][C:27]3[C:34]4[C:39]([CH:40]=[CH:41][C:26]2=3)=[CH:38][CH:37]=[CH:36][CH:35]=4)=[CH:21][CH:20]=1)=[O:9])([CH3:2])[CH3:3]